Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.
نویسندگان
چکیده
The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 92 شماره
صفحات -
تاریخ انتشار 2012